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selective nmda receptor antagonist  (Tocris)


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    Tocris selective nmda receptor antagonist
    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
    Selective Nmda Receptor Antagonist, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 2070 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 96 stars, based on 2070 article reviews
    selective nmda receptor antagonist - by Bioz Stars, 2026-06
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    1) Product Images from "Compound- and sex-specific medial prefrontal cortex rewiring after prenatal THC and CBD exposure"

    Article Title: Compound- and sex-specific medial prefrontal cortex rewiring after prenatal THC and CBD exposure

    Journal: bioRxiv

    doi: 10.64898/2026.02.13.705680

    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in the AMPA/NMDA ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
    Figure Legend Snippet: (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in the AMPA/NMDA ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.

    Techniques Used: MANN-WHITNEY, Comparison



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    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
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    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
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    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
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    Image Search Results


    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in the AMPA/NMDA ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.

    Journal: bioRxiv

    Article Title: Compound- and sex-specific medial prefrontal cortex rewiring after prenatal THC and CBD exposure

    doi: 10.64898/2026.02.13.705680

    Figure Lengend Snippet: (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in the AMPA/NMDA ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.

    Article Snippet: GABA-sIPSCs were recorded at − 70 mV in presence of 20 μM CNQX (6-Cyano-7-nitroquinoxaline-2,3-dione disodium, an AMPA receptor antagonist, Tocris) and L-APV 50 μM (DL-2-Amino-5-phosphonopentanoic acid, a selective NMDA receptor antagonist, Tocris).

    Techniques: MANN-WHITNEY, Comparison